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Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy

Patients with cancer frequently receive immune-checkpoint inhibitors (ICIs), which may modulate immune responses to COVID-19 vaccines. Recently, cytokine release syndrome (CRS) was observed in a patient with cancer who received BTN162b2 vaccination under ICI treatment. Here, we analyzed adverse even...

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Main Authors: Walle, Thomas (Author) , Bajaj, Sunanjay (Author) , Kraske, Joscha (Author) , Rösner, Thomas (Author) , Cussigh, Christiane (Author) , Kälber, Katharina (Author) , Müller, Lisa Jasmin (Author) , Strobel, Sophia (Author) , Burghaus-Zhang, Jana (Author) , Kallenberger, Stefan M. (Author) , Stein-Thöringer, Christoph (Author) , Jenzer, Maximilian (Author) , Schubert, Antonia (Author) , Kahle, Steffen (Author) , Williams, Anja (Author) , Hoyler, Birgit (Author) , Zielske, Lin (Author) , Skatula, Renate (Author) , Sawall, Stefanie (Author) , Leber, Mathias Felix (Author) , Kunes, Russell Z. (Author) , Krisam, Johannes (Author) , Fremd, Carlo (Author) , Schneeweiss, Andreas (Author) , Krauß, Jürgen (Author) , Apostolidis, Leonidas (Author) , Berger, Anne Katrin (Author) , Haag, Georg Martin (Author) , Zschäbitz, Stefanie (Author) , Halama, Niels (Author) , Springfeld, Christoph (Author) , Kirsten, Romy (Author) , Hassel, Jessica C. (Author) , Jäger, Dirk (Author) , Ungerechts, Guy (Author)
Format: Article (Journal)
Language:English
Published: 17 June 2022
In: Nature cancer
Year: 2022, Volume: 3, Issue: 9, Pages: 1039-1051
ISSN:2662-1347
DOI:10.1038/s43018-022-00398-7
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s43018-022-00398-7
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s43018-022-00398-7
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Author Notes:Thomas Walle, Sunanjay Bajaj, Joscha A. Kraske, Thomas Rösner, Christiane S. Cussigh, Katharina A. Kälber, Lisa Jasmin Müller, Sophia Boyoung Strobel, Jana Burghaus, Stefan M. Kallenberger, Christoph K. Stein-Thöringer, Maximilian Jenzer, Antonia Schubert, Steffen Kahle, Anja Williams, Birgit Hoyler, Lin Zielske, Renate Skatula, Stefanie Sawall, Mathias F. Leber, Russell Z. Kunes, Johannes Krisam, Carlo Fremd, Andreas Schneeweiss, Jürgen Krauss, Leonidas Apostolidis, Anne Katrin Berger, Georg M. Haag, Stefanie Zschäbitz, Niels Halama, Christoph Springfeld, Romy Kirsten, Jessica C. Hassel, Dirk Jäger and Guy Ungerechts
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Summary:Patients with cancer frequently receive immune-checkpoint inhibitors (ICIs), which may modulate immune responses to COVID-19 vaccines. Recently, cytokine release syndrome (CRS) was observed in a patient with cancer who received BTN162b2 vaccination under ICI treatment. Here, we analyzed adverse events and serum cytokines in patients with 23 different tumors undergoing (n = 64) or not undergoing (n = 26) COVID-19 vaccination under ICI therapy in a prospectively planned German single-center cohort study (n = 220). We did not observe clinically relevant CRS (≥grade 2) after vaccination (95% CI 0-5.6%; Common Terminology of Adverse Events v.5.0) in this small cohort. Within 4 weeks after vaccination, serious adverse events occurred in eight patients (12.5% 95% CI 5.6-23%), six patients were hospitalized and two patients died. Despite absence of CRS symptoms, a set of pairwise-correlated CRS-associated cytokines, including CXCL8 and interleukin-6 was >1.5-fold upregulated in 40% (95% CI 23.9-57.9%) of patients after vaccination. Hence, elevated cytokine levels are common and not sufficient to establish CRS diagnosis.
Item Description:Das PDF enthält zusätzlich einen Anhang von 14 Seiten
Gesehen am 07.07.2022
Physical Description:Online Resource
ISSN:2662-1347
DOI:10.1038/s43018-022-00398-7

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