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Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents

During deep anesthesia, the electroencephalographic (EEG) signal of the brain alternates between bursts of activity and periods of relative silence (suppressions). The origin of burst-suppression and its distribution across the brain remain matters of debate. In this work, we used functional magneti...

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Main Authors: Sirmpilatze, Nikoloz (Author) , Mylius, Judith (Author) , Ortiz-Rios, Michael (Author) , Baudewig, Jürgen (Author) , Paasonen, Jaakko (Author) , Golkowski, Daniel (Author) , Ranft, Andreas (Author) , Ilg, Rüdiger (Author) , Gröhn, Olli (Author) , Boretius, Susann (Author)
Format: Article (Journal)
Language:English
Published: May 24, 2022
In: eLife
Year: 2022, Volume: 11, Pages: 1-31
ISSN:2050-084X
DOI:10.7554/eLife.74813
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.74813
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Author Notes:Nikoloz Sirmpilatze, Judith Mylius, Michael Ortiz-Rios, Jürgen Baudewig, Jaakko Paasonen, Daniel Golkowski, Andreas Ranft, Rüdiger Ilg, Olli Gröhn, Susann Boretius
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Summary:During deep anesthesia, the electroencephalographic (EEG) signal of the brain alternates between bursts of activity and periods of relative silence (suppressions). The origin of burst-suppression and its distribution across the brain remain matters of debate. In this work, we used functional magnetic resonance imaging (fMRI) to map the brain areas involved in anesthesia-induced burst-suppression across four mammalian species: humans, long-tailed macaques, common marmosets, and rats. At first, we determined the fMRI signatures of burst-suppression in human EEG-fMRI data. Applying this method to animal fMRI datasets, we found distinct burst-suppression signatures in all species. The burst-suppression maps revealed a marked inter-species difference: in rats, the entire neocortex engaged in burst-suppression, while in primates most sensory areas were excluded—predominantly the primary visual cortex. We anticipate that the identified species-specific fMRI signatures and whole-brain maps will guide future targeted studies investigating the cellular and molecular mechanisms of burst-suppression in unconscious states.
Item Description:Gesehen am 08.07.2022
Physical Description:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.74813

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