PLP-dependent enzymes as potential drug targets for protozoan diseases
The chemical properties of the B6 vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B6 dependent enzymatic reactions as drug targets. Several current targets are descri...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 July 2011
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| In: |
Biochimica et biophysica acta. Proteins and proteomics
Year: 2011, Volume: 1814, Issue: 11, Pages: 1567-1576 |
| ISSN: | 1878-1454 |
| DOI: | 10.1016/j.bbapap.2011.07.018 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbapap.2011.07.018 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1570963911002135 
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| Author Notes: | Barbara Kappes, Ivo Tews, Alexandra Binter, Peter Macheroux |
| Summary: | The chemical properties of the B6 vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B6 dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology. |
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| Item Description: | Gesehen am 11.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1878-1454 |
| DOI: | 10.1016/j.bbapap.2011.07.018 |