Temporal profile of release of interleukin-1β in neurotrauma
Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotra...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 April 2000
|
| In: |
Neuroscience letters
Year: 2000, Jahrgang: 284, Heft: 3, Pages: 135-138 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/s0304-3940(00)00977-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0304-3940(00)00977-0
|
| Verfasserangaben: | Klaus Fassbender, Susanne Schneider, Thomas Bertsch, Dirk Schlueter, Marc Fatar, Andreas Ragoschke, Sandra Kühl, Udo Kischka, Michael Hennerici |
| Zusammenfassung: | Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1beta was detected whereas immunoreactivity for the IL-1beta protein was negative. Concentrations of extracellularly secreted IL-1beta protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1beta secretion. This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response. |
|---|---|
| Beschreibung: | Gesehen am 13.07.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/s0304-3940(00)00977-0 |