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Role of endothelial cell lipoprotein lipase for brown adipose tissue lipid and glucose handling

Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL). Lipoprotein lipase (LPL) expressed by adipocytes is translocated via endothelial to the capillary lumen...

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Main Authors: Thiemann, Ellen (Author) , Schwaerzer, Gerburg K. (Author) , Evangelakos, Ioannis (Author) , Fuh, Marceline M. (Author) , Jaeckstein, Michelle Y. (Author) , Behrens, Janina (Author) , Nilsson, Stefan K. (Author) , Kumari, Manju (Author) , Scheja, Ludger (Author) , Pfeifer, Alexander (Author) , Heeren, Jörg (Author) , Heine, Markus (Author)
Format: Article (Journal)
Language:English
Published: 29 March 2022
In: Frontiers in physiology
Year: 2022, Volume: 13, Pages: 1-11
ISSN:1664-042X
DOI:10.3389/fphys.2022.859671
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fphys.2022.859671
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fphys.2022.859671
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Author Notes:Ellen Thiemann, Gerburg K. Schwaerzer, Ioannis Evangelakos, Marceline M. Fuh, Michelle Y. Jaeckstein, Janina Behrens, Stefan K. Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren and Markus Heine
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Summary:Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL). Lipoprotein lipase (LPL) expressed by adipocytes is translocated via endothelial to the capillary lumen, where LPL acts as the central enzyme for the vascular lipoprotein processing. Based on preliminary data showing that LPL is not only expressed in adipocytes but also in endothelial cells of cold-activated BAT, we aimed to dissect the relevance of endothelial versus adipocyte LPL for lipid and energy metabolism in the context of adaptive thermogenesis. By metabolic studies we found that cold-induced triglyceride uptake into BAT, lipoprotein disposal, glucose uptake and adaptive thermogenesis were not impaired in mice lacking Lpl exclusively in endothelial cells. This finding may be explained by a compensatory upregulation in the expression of adipocyte-derived Lpl and endothelial lipase (Lipg).
Item Description:Gesehen am 19.07.2022
Physical Description:Online Resource
ISSN:1664-042X
DOI:10.3389/fphys.2022.859671

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