Acceleration of thrombolysis with ultrasound through the cranium in a flow model
Thrombolysis is an efficient therapy for hyperacute stroke within a limited time window. Neurological outcome depends on the recanalization time of the occluded vessel. Nonthermal effects of low-frequency ultrasound (US) accelerate enzymatic fibrinolysis in vitro. We examined the effects of transcra...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 August 2000
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| In: |
Ultrasound in medicine & biology
Year: 2000, Volume: 26, Issue: 5, Pages: 889-895 |
| ISSN: | 1879-291X |
| DOI: | 10.1016/s0301-5629(00)00211-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0301-5629(00)00211-8
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| Author Notes: | Konstantinos Spengos, Stephan Behrens, Michael Daffertshofer, Carl E. Dempfle and Michael Hennerici |
| Summary: | Thrombolysis is an efficient therapy for hyperacute stroke within a limited time window. Neurological outcome depends on the recanalization time of the occluded vessel. Nonthermal effects of low-frequency ultrasound (US) accelerate enzymatic fibrinolysis in vitro. We examined the effects of transcranially applied US on recombinant tissue plasminogen activator (rt-PA)-mediated thrombolysis in a flow model in vitro. Pure fibrin clots were placed in a continuous-pressure flow model and treated with rt-PA during 1-MHz US exposure (0.5 W/cm(2); spatial peak, temporal peak intensity). Transcranial and direct US application in combination with rt-PA significantly (p<0.001) shortened recanalization time, increased perfusion flow and reperfusion rate in comparison with rt-PA-mediated thrombolysis alone. Recanalization rate within 30 min was 90-100% in the US-exposed clots vs. 30% in the clots treated only with rt-PA. Our results suggest that transcranial application of 1-MHz US may accelerate reperfusion and recanalization rate of occluded intracerebral vessels by enhancing rt-PA-mediated thrombolysis. Shortening of recanalization time could contribute to optimizing effects of acute thrombolytic stroke therapy. |
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| Item Description: | Gesehen am 19.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1879-291X |
| DOI: | 10.1016/s0301-5629(00)00211-8 |