Cover Image

Secondary malignancy risk following proton vs. X-ray radiotherapy of thymic epithelial tumors: a comparative modeling study of thoracic organ-specific cancer risk

Background: Proton beam radiotherapy (PBT) offers physical dose advantages that might reduce the risk for secondary malignancies (SM). The aim of the current study is to calculate the risk for SM after X-ray-based 3D conformal (3DCRT) radiotherapy, intensity-modulated radiotherapy (IMRT), and active...

Full description

Saved in:
Bibliographic Details
Main Authors: König, Laila (Author) , Hörner-Rieber, Juliane (Author) , Forsthoefel, Matthew (Author) , Häring, Peter (Author) , Meixner, Eva (Author) , Eichkorn, Tanja (Author) , Krämer, Anna Sabrina (Author) , Mielke, Thomas (Author) , Tonndorf-Martini, Eric (Author) , Häfner, Matthias (Author) , Debus, Jürgen (Author) , Lischalk, Jonathan W. (Author)
Format: Article (Journal)
Language:English
Published: 13 May 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 10, Pages: 1-12
ISSN:2072-6694
DOI:10.3390/cancers14102409
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14102409
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/10/2409
Get full text
Author Notes:Laila König, Juliane Hörner-Rieber, Matthew Forsthoefel, Peter Haering, Eva Meixner, Tanja Eichkorn, Anna Krämer, Thomas Mielke, Eric Tonndorf-Martini, Matthias F. Haefner, Jürgen Debus and Jonathan W. Lischalk
Description
Summary:Background: Proton beam radiotherapy (PBT) offers physical dose advantages that might reduce the risk for secondary malignancies (SM). The aim of the current study is to calculate the risk for SM after X-ray-based 3D conformal (3DCRT) radiotherapy, intensity-modulated radiotherapy (IMRT), and active pencil beam scanned proton therapy (PBS) in patients treated for thymic malignancies. Methods: Comparative treatment plans for each of the different treatment modalities were generated for 17 patients. The risk for radiation-induced SM was estimated using two distinct prediction models—the Dasu and the Schneider model. Results: The total and fatal SM risks estimated using the Dasu model demonstrated significant reductions with the use of PBS relative to both 3DCRT and IMRT for all independent thoracic organs analyzed with the exception of the thyroid gland (p ≤ 0.001). SM rates per 10,000 patients per year per Gy evaluated using the Schneider model also resulted in significant reductions with the use of PBS relative to 3DCRT and IMRT for the lungs, breasts, and esophagus (p ≤ 0.001). Conclusions: PBS achieved superior sparing of relevant OARs compared to 3DCRT and IMRT, leading to a lower risk for radiation-induced SM. PBS should therefore be considered in patients diagnosed with thymic malignancies, particularly young female patients.
Item Description:Gesehen am 20.07.2022
This article belongs to the special issue "Personalized radiation therapy for oncology"
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14102409

Similar Items