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Role of ABO blood group in SARS-CoV-2 infection in households

An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh bloo...

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Main Authors: Janda, Ales̆ (Author) , Engel, Corinna (Author) , Remppis, Jonathan (Author) , Enkel, Sigrid (Author) , Peter, Andreas (Author) , Hörber, Sebastian (Author) , Ganzenmueller, Tina (Author) , Schober, Sarah (Author) , Weinstock, Christof (Author) , Jacobsen, Eva-Maria (Author) , Fabricius, Dorit (Author) , Zernickel, Maria (Author) , Stamminger, Thomas (Author) , Dietz, Andrea (Author) , Groß, Hans-Jürgen (Author) , Bode, Sebastian F. N. (Author) , Haddad, Anneke D. M. (Author) , Elling, Roland (Author) , Stich, Maximilian (Author) , Tönshoff, Burkhard (Author) , Henneke, Philipp (Author) , Debatin, Klaus-Michael (Author) , Franz, Axel R. (Author) , Renk, Hanna (Author)
Format: Article (Journal)
Language:English
Published: 06 May 2022
In: Frontiers in microbiology
Year: 2022, Volume: 13, Pages: 1-8
ISSN:1664-302X
Online Access:Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fmicb.2022.857965
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Author Notes:Ales Janda, Corinna Engel, Jonathan Remppis, Sigrid Enkel, Andreas Peter, Sebastian Hörber, Tina Ganzenmueller, Sarah Schober, Christof Weinstock, Eva-Maria Jacobsen, Dorit Fabricius, Maria Zernickel, Thomas Stamminger, Andrea Dietz, Hans-Jürgen Groß, Sebastian F.N. Bode, Anneke D.M. Haddad, Roland Elling, Maximilian Stich, Burkhard Tönshoff, Philipp Henneke, Klaus-Michael Debatin, Axel R. Franz and Hanna Renk
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Summary:An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children.
Item Description:Gesehen am 20.07.2022
Physical Description:Online Resource
ISSN:1664-302X

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