Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases
OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). - RESULTS: IL-18 concentrations in CS...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 1, 1999
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| In: |
Neurology
Year: 1999, Volume: 53, Issue: 5, Pages: 1104-1106 |
| ISSN: | 1526-632X |
| DOI: | 10.1212/wnl.53.5.1104 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1212/wnl.53.5.1104
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| Author Notes: | K. Fassbender, O. Mielke, T. Bertsch, F. Muehlhauser, M. Hennerici, M. Kurimoto, and S. Rossol |
| Summary: | OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). - RESULTS: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. - CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS. |
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| Item Description: | Gesehen am 27.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1526-632X |
| DOI: | 10.1212/wnl.53.5.1104 |