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Preoperative shock wave treatment enhances ischemic tissue survival, blood flow and angiogenesis in a rat skin flap model

Introduction - Extracorporeal shock wave treatment (ESWT) has recently been shown to enhance skin flap survival. However, the bio-mechanisms operating during preoperative ESWT remain unclear. The aim of our study was to investigate whether preoperative ESWT can improve blood flow in ischemic skin fl...

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Main Authors: Keil, Holger (Author) , Müller, Wolf C. (Author) , Herold-Mende, Christel (Author) , Gebhard, Martha-Maria (Author) , Germann, Günter (Author) , Engel, Holger (Author) , Reichenberger, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 21 January 2011
In: International journal of surgery
Year: 2011, Volume: 9, Issue: 4, Pages: 292-296
ISSN:1743-9159
DOI:10.1016/j.ijsu.2011.01.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijsu.2011.01.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1743919111000045
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Author Notes:Holger Keil, Wolf Mueller, Christel Herold-Mende, Martha Maria Gebhard, Günter Germann, Holger Engel, Matthias A. Reichenberger
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Summary:Introduction - Extracorporeal shock wave treatment (ESWT) has recently been shown to enhance skin flap survival. However, the bio-mechanisms operating during preoperative ESWT remain unclear. The aim of our study was to investigate whether preoperative ESWT can improve blood flow in ischemic skin flaps and to elucidate its possible mechanisms. - Methods - 14 male-rats were randomized into two groups and an oversized ventral random-pattern flap was raised. Experimental group received extracorporeal shock-wave treatment (ESWT) with an energy of 500 mJ/mm2 seven days prior to total flap elevation, while control group received no treatment prior to total flap elevation. Seven days postoperatively, surviving flap area, perfused flap area, microvessel density and VEGF concentration were measured. - Results - Surviving flap area (59.43 ± 14.72 % to 42.71 ± 10.75 %, p = 0.026), perfused flap area (62.00 ± 8.58 % to 45.14 ± 10.50 %, p = 0.007), microvessel density (18.13 ± 5.11 to 11.09 ± 1.12, p = 0.016) and VEGF to total protein ratio (0.2107 ± 0.0935 to 0.0123 ± 0.0069, p = 0.008) were significantly elevated in the ESWT group. - Conclusion - Preoperative ESWT can improve skin flap survival through enhanced topical blood perfusion and neovascularization via elevation of angio-active factors.
Item Description:Gesehen am 28.07.2022
Physical Description:Online Resource
ISSN:1743-9159
DOI:10.1016/j.ijsu.2011.01.003

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