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Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro

Hepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette protein (ABC-transport protein) mediated multidrug resistance in cancer cells. The aim of...

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Bibliographic Details
Main Authors: Hoffmann, Katrin (Author) , Xiao, Zhi (Author) , Franz, Clemens (Author) , Mohr, Elvira (Author) , Serba, Susanne (Author) , Büchler, Markus W. (Author) , Schemmer, Peter (Author)
Format: Article (Journal)
Language:English
Published: 17 November 2011
In: Cancer cell international
Year: 2011, Volume: 11, Pages: 1-9
ISSN:1475-2867
DOI:10.1186/1475-2867-11-40
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2867-11-40
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Author Notes:Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Susanne Serba, Markus W. Büchler and Peter Schemmer
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Summary:Hepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette protein (ABC-transport protein) mediated multidrug resistance in cancer cells. The aim of this study was to examine whether EGFR inhibition sensitizes HCCs to chemotherapy and to elucidate its mechanism.
Item Description:Gesehen am 29.07.2022
Physical Description:Online Resource
ISSN:1475-2867
DOI:10.1186/1475-2867-11-40

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