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Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis

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Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum. Benfotiamine dec...

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Main Authors: Kihm, Lars Philipp (Author) , Müller-Krebs, Sandra (Author) , Klein, Julia (Author) , Ehrlich, Gregory Marius (Author) , Mertes, Laura (Author) , Groß-Weissmann, Marie-Luise (Author) , Adaikalakoteswari, Antonysunil (Author) , Thornalley, Paul J. (Author) , Hammes, Hans-Peter (Author) , Nawroth, Peter Paul (Author) , Zeier, Martin (Author) , Schwenger, Vedat (Author)
Format: Article (Journal)
Language:English
Published: April 29, 2011
In: Journal of the American Society of Nephrology
Year: 2011, Volume: 22, Issue: 5, Pages: 914-926
ISSN:1533-3450
DOI:10.1681/ASN.2010070750
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1681/ASN.2010070750
Verlag, lizenzpflichtig, Volltext: https://jasn.asnjournals.org/content/22/5/914
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Author Notes:Lars P. Kihm, Sandra Müller-Krebs, Julia Klein, Gregory Ehrlich, Laura Mertes, Marie-Luise Gross, Antonysunil Adaikalakoteswari, Paul J. Thornalley, Hans-Peter Hammes, Peter P. Nawroth, Martin Zeier, and Vedat Schwenger
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Summary:Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum. Benfotiamine decreases glucose-induced tissue damage, suggesting the potential for benefit in peritoneal dialysis. Here, in a model of peritoneal dialysis in uremic rats, treatment with benfotiamine decreased peritoneal fibrosis, markers of inflammation, and neovascularization, resulting in improved characteristics of peritoneal transport. Furthermore, rats treated with benfotiamine exhibited lower expression of advanced glycation endproducts and their receptor in the peritoneum and the kidney, reduced glomerular and tubulointerstitial damage, and less albuminuria. Increased activity of transketolase in tissue and blood contributed to the protective effects of benfotiamine. In primary human peritoneal mesothelial cells, the addition of benfotiamine led to enhanced transketolase activity and decreased expression of advanced glycation endproducts and their receptor. Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia.
Item Description:Gesehen am 04.08.2022
Physical Description:Online Resource
ISSN:1533-3450
DOI:10.1681/ASN.2010070750

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