Mechanisms and therapeutic targets for neuropathic itch
Neuropathic pruritus conditions arise from structural and/or functional damage of the peripheral or central nervous system. Novel findings of pruritus specific mediators and pathways strengthen the specificity theory of pruritus transmission, however electrophysiological studies suggest that focal a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 June 2022
|
| In: |
Current opinion in neurobiology
Year: 2022, Volume: 75, Pages: 1-7 |
| ISSN: | 1873-6882 |
| DOI: | 10.1016/j.conb.2022.102573 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.conb.2022.102573
|
| Author Notes: | Manuel Pedro Pereira, Martin Schmelz and Sonja Ständer |
| Summary: | Neuropathic pruritus conditions arise from structural and/or functional damage of the peripheral or central nervous system. Novel findings of pruritus specific mediators and pathways strengthen the specificity theory of pruritus transmission, however electrophysiological studies suggest that focal activation of nociceptors and distinct discharge patterns of primary afferents also contribute to the development of the sensation of pruritus. A complex interplay between excitatory and inhibitory interneurons at spinal level, non-neuronal cells and descending modulation from upper centers contributes to neuronal sensitization and clinically to the chronicity of pruritus, as well as accompanying phenomena such as alloknesis and hyperknesis. Several topical, systemic and non-pharmacological therapeutic approaches directed at distinct targets are currently available. |
|---|---|
| Item Description: | Gesehen am 04.08.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-6882 |
| DOI: | 10.1016/j.conb.2022.102573 |