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Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We...

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Main Authors: Täubert, Minerva Jazmin (Author) , de Prado-Bert, P. (Author) , Geurtsen, M. L. (Author) , Mancano, G. (Author) , Vermeulen, M. J. (Author) , Reiss, I. K. M. (Author) , Caramaschi, D. (Author) , Sunyer, J. (Author) , Sharp, G. C. (Author) , Julvez, J. (Author) , Muckenthaler, Martina (Author) , Felix, J. F. (Author)
Format: Article (Journal)
Language:English
Published: 03 May 2022
In: Clinical epigenetics
Year: 2022, Volume: 14, Issue: 1, Pages: 1-12
ISSN:1868-7083
DOI:10.1186/s13148-022-01276-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-022-01276-w
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Author Notes:M.J. Taeubert, P. de Prado-Bert, M.L. Geurtsen, G. Mancano, M.J. Vermeulen, I.K.M. Reiss, D. Caramaschi, J. Sunyer, G.C. Sharp, J. Julvez, M.U. Muckenthaler and J.F. Felix
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Summary:Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We performed a meta-analysis on the association of maternal early-pregnancy serum ferritin concentrations, as a marker of body iron stores, and cord blood DNA methylation. We included 1286 mother-newborn pairs from two population-based prospective cohorts. Serum ferritin concentrations were measured in early pregnancy. DNA methylation was measured with the Infinium HumanMethylation450 BeadChip (Illumina). We examined epigenome-wide associations of maternal early-pregnancy serum ferritin and cord blood DNA methylation using robust linear regression analyses, with adjustment for confounders and performed fixed-effects meta-analyses. We additionally examined whether associations of any CpGs identified in cord blood persisted in the peripheral blood of older children and explored associations with other markers of maternal iron status. We also examined whether similar findings were present in the association of cord blood serum ferritin concentrations with cord blood DNA methylation.
Item Description:Gesehen am 05.08.2022
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-022-01276-w

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