Cover Image

[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells

We demonstrate the cytotoxic potential of the Schiff base iron complex [FeIII(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [FeIII(salophen...

Full description

Saved in:
Bibliographic Details
Main Authors: Lee, Soo-Young (Author) , Hille, Annegret (Author) , Kitanovic, Igor (Author) , Jesse, Patrick (Author) , Henze, Günter (Author) , Wölfl, Stefan (Author) , Gust, Ronald (Author) , Prokop, Aram (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Leukemia research
Year: 2011, Volume: 35, Issue: 3, Pages: 387-393
ISSN:1873-5835
DOI:10.1016/j.leukres.2010.11.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.leukres.2010.11.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0145212610005369
Get full text
Author Notes:Soo-Young Lee, Annegret Hille, Igor Kitanovic, Patrick Jesse, Günter Henze, Stefan Wölfl, Ronald Gust, Aram Prokop
Description
Summary:We demonstrate the cytotoxic potential of the Schiff base iron complex [FeIII(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [FeIII(salophene)Cl] led to the exclusion of unspecific necrosis, a concentration-dependent inhibition of proliferation and a specific apoptotic cell death. We further detected a significant loss of the mitochondrial membrane potential in lymphoma cells and an up- and downregulation of various apoptosis relevant genes, respectively, indicating the involvement of the intrinsic mitochondrial pathway.
Item Description:Available online 4 December 2010
Im Titel ist III bei "Fe" hochgestellt
Gesehen am 08.08.2022
Physical Description:Online Resource
ISSN:1873-5835
DOI:10.1016/j.leukres.2010.11.007

Similar Items