Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women
We assessed whether long-term exposure to air pollution is associated with all-cause and cause-specific mortality during a period of declining particulate matter concentrations. - Approximately 4800 women aged 55 years from North Rhine-Westphalia, Germany, were followed for up to 18 years. Exposure...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
Occupational and environmental medicine
Year: 2013, Volume: 70, Issue: 3, Pages: 179-186 |
| ISSN: | 1470-7926 |
| DOI: | 10.1136/oemed-2012-100876 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1136/oemed-2012-100876 Verlag, lizenzpflichtig, Volltext: https://oem.bmj.com/content/70/3/179 
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| Author Notes: | Joachim Heinrich, Elisabeth Thiering, Peter Rzehak, Ursula Krämer, Matthias Hochadel, Knut M. Rauchfuss, Ulrike Gehring, H.-Erich Wichmann |
| Summary: | We assessed whether long-term exposure to air pollution is associated with all-cause and cause-specific mortality during a period of declining particulate matter concentrations. - Approximately 4800 women aged 55 years from North Rhine-Westphalia, Germany, were followed for up to 18 years. Exposure to air pollution was assessed in two ways: (1) using the distance between the residential address and the nearest major road, as calculated from Geographic Information System data and (2) calculating 1-year average particulate matter concentrations below 10 µm (PM10) and nitrogen dioxide (NO2) levels using data from the nearest air-monitoring station data to the subjects’ residences. Ninety-two per cent of all subjects lived in the same community during the entire follow-up period. Associations between mortality and exposure were assessed using Cox's proportional hazards models, including confounder adjustment. - Sixteen per cent of women passed away during the follow-up period. An increase of 7 μg/m3 PM10 (IQR) was associated with an increased HR for all-cause (HR 1.15, 95% CI (1.04 to 1.27)), cardiopulmonary (HR 1.39, 95% CI (1.17 to 1.64)), and lung cancer mortality (HR 1.84, 95% CI (1.23 to 2.74)). An increase of 16 μg/m3 (IQR) NO2 exposure was associated with all-cause (HR 1.18, 95% CI (1.07 to 1.30)) and cardiopulmonary mortality (HR 1.55, 95% CI (1.30 to 1.84)). The association between cardiopulmonary mortality and PM10 was reduced for the extended follow-up period, during which PM10 concentrations (but not NO2 concentrations) were lower. Living close to a major road was associated with an increased relative risk for all-cause, cardiopulmonary and respiratory mortality. These associations were temporally stable. - Long-term exposure to ambient PM10 and NO2 was associated with increased mortality rates. |
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| Item Description: | Published online first 8 December 2012 Im Titel sind die Zahlen "2" und "10" tiefgestellt Gesehen am 15.08.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1470-7926 |
| DOI: | 10.1136/oemed-2012-100876 |