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N-cadherin distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas

Carcinomas of the pancreatobiliary system confer an especially unfavorable prognosis. The differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and its subtypes versus liver metastasis of ductal adenocarcinoma of the pancreas (PDAC) is clinically important to allow the best possible thera...

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Main Authors: Gerber, Tiemo Sven (Author) , Goeppert, Benjamin (Author) , Hausen, Anne (Author) , Witzel, Hagen Roland (Author) , Bartsch, Fabian (Author) , Schindeldecker, Mario (Author) , Gröger, Lisa-Katharina (Author) , Ridder, Dirk (Author) , Cahyadi, Oscar (Author) , Esposito, Irene (Author) , Gaida, Matthias (Author) , Schirmacher, Peter (Author) , Galle, Peter R. (Author) , Lang, Hauke (Author) , Roth, Wilfried (Author) , Straub, Beate Katharina (Author)
Format: Article (Journal)
Language:English
Published: 23 June 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 13, Pages: 1-18
ISSN:2072-6694
DOI:10.3390/cancers14133091
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14133091
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Author Notes:Tiemo S. Gerber, Benjamin Goeppert, Anne Hausen, Hagen R. Witzel, Fabian Bartsch, Mario Schindeldecker, Lisa-Katharina Gröger, Dirk A. Ridder, Oscar Cahyadi, Irene Esposito, Matthias M. Gaida, Peter Schirmacher, Peter R. Galle, Hauke Lang, Wilfried Roth and Beate K. Straub
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Summary:Carcinomas of the pancreatobiliary system confer an especially unfavorable prognosis. The differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and its subtypes versus liver metastasis of ductal adenocarcinoma of the pancreas (PDAC) is clinically important to allow the best possible therapy. We could previously show that E-cadherin and N-cadherin, transmembrane glycoproteins of adherens junctions, are characteristic features of hepatocytes and cholangiocytes. We therefore analyzed E-cadherin and N-cadherin in the embryonally related epithelia of the bile duct and pancreas, as well as in 312 iCCAs, 513 carcinomas of the extrahepatic bile ducts, 228 gallbladder carcinomas, 131 PDACs, and precursor lesions, with immunohistochemistry combined with image analysis, fluorescence microscopy, and immunoblots. In the physiological liver, N-cadherin colocalizes with E-cadherin in small intrahepatic bile ducts, whereas larger bile ducts and pancreatic ducts are positive for E-cadherin but contain decreasing amounts of N-cadherin. N-cadherin was highly expressed in most iCCAs, whereas in PDACs, N-cadherin was negative or only faintly expressed. E- and N-cadherin expression in tumors of the pancreaticobiliary tract recapitulate their expression in their normal tissue counterparts. N-cadherin is a helpful marker for the differential diagnosis between iCCA and PDAC, with a specificity of 96% and a sensitivity of 67% for small duct iCCAs and 50% for large duct iCCAs.
Item Description:Gesehen am 17.08.2022
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14133091

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