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Concurrent change in serum cholinesterase activity and midregional-proadrennomedullin level could predict patient outcome following liver transplantation

Background: After liver transplantation (LTX), patients are susceptible to opportunistic infections resulting in reduced outcomes within the early post-transplantation period. The postoperative monitoring of LTX patients has gained much importance in recent years. However, reliable plasmatic markers...

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Main Authors: Decker, Sebastian (Author) , Krüger, Albert (Author) , Wilk, Henryk (Author) , Uhle, Florian (Author) , Bruckner, Thomas (Author) , Hofer, Stefan (Author) , Weigand, Markus A. (Author) , Brenner, Thorsten (Author) , Živković, Aleksandar (Author)
Format: Article (Journal)
Language:English
Published: 15 July 2022
In: Biomolecules
Year: 2022, Volume: 12, Issue: 7, Pages: 1-17
ISSN:2218-273X
DOI:10.3390/biom12070989
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/biom12070989
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2218-273X/12/7/989
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Author Notes:Sebastian O. Decker, Albert Krüger, Henryk Wilk, Florian Uhle, Thomas Bruckner, Stefan Hofer, Markus A. Weigand, Thorsten Brenner and Aleksandar R. Zivkovic
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Summary:Background: After liver transplantation (LTX), patients are susceptible to opportunistic infections resulting in reduced outcomes within the early post-transplantation period. The postoperative monitoring of LTX patients has gained much importance in recent years. However, reliable plasmatic markers predicting 90-day outcomes are still lacking. Methods: In the post hoc analysis of a prospective, observational study, butyrylcholinesterase (BChE), mid-regional proadrenomedullin (MR-proADM), as well as conventional inflammatory markers (procalcitonin, C-reactive protein) were evaluated in 93 patients at seven consecutive timepoints within the first 28 days following LTX. Results: Persistently reduced activity of BChE and elevated MR-proADM levels indicated reduced 90-day survival following LTX. Furthermore, reduced BChE and increased MR-proADM activity could indicate early post-transplantation bacterial infections, whereas conventional inflammatory biomarkers showed no diagnostic efficacy within the observation period. Conclusion: Concurrent assessment of BChE and MR-proADM activity might serve as a bedside diagnostic tool for early bacterial infections following liver transplantation. Thus, a combined utilization of the two biomarkers may be a useful tool in the risk evaluation of patients following liver transplantation.
Item Description:Gesehen am 19.08.2022
Physical Description:Online Resource
ISSN:2218-273X
DOI:10.3390/biom12070989

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