Functional organization of RNA polymerase II in nuclear subcompartments
Distinct clusters of RNA polymerase II are responsible for gene transcription inside eukaryotic cell nuclei. Despite the functional implications of such subnuclear organization, the attributes of these clusters and the mechanisms underlying their formation remain only partially understood. Recently,...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 February 2022
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| In: |
Current opinion in cell biology
Year: 2022, Volume: 74, Pages: 88-96 |
| ISSN: | 1879-0410 |
| DOI: | 10.1016/j.ceb.2022.01.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ceb.2022.01.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0955067422000060 
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| Author Notes: | Karsten Rippe and Argyris Papantonis |
| Summary: | Distinct clusters of RNA polymerase II are responsible for gene transcription inside eukaryotic cell nuclei. Despite the functional implications of such subnuclear organization, the attributes of these clusters and the mechanisms underlying their formation remain only partially understood. Recently, the concept of proteins and RNA phase-separating into liquid-like droplets was proposed to drive the formation of transcriptionally-active subcompartments. Here, we attempt to reconcile previous with more recent findings, and discuss how the different ways of assembling the active RNA polymerase II transcriptional machinery relate to nuclear compartmentalization. |
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| Item Description: | Part of special issue: SI: cell nucleus 2022 Gesehen am 19.08.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0410 |
| DOI: | 10.1016/j.ceb.2022.01.005 |