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Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout lead...

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Main Authors: Oehler, Daniel (Author) , Spychala, André (Author) , Gödecke, Axel (Author) , Lang, Alexander (Author) , Gerdes, Norbert (Author) , Ruas, Jorge (Author) , Kelm, Malte (Author) , Szendrödi, Julia (Author) , Westenfeld, Ralf (Author)
Format: Article (Journal)
Language:English
Published: 30 July 2022
In: BMC biology
Year: 2022, Volume: 20, Pages: 1-20
ISSN:1741-7007
DOI:10.1186/s12915-022-01360-w
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12915-022-01360-w
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Author Notes:Daniel Oehler, André Spychala, Axel Gödecke, Alexander Lang, Norbert Gerdes, Jorge Ruas, Malte Kelm, Julia Szendroedi and Ralf Westenfeld
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Summary:Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout leads to dilatative cardiomyopathy, but knowledge on the complexity of cardiac isoform expression of PGC-1α remains sparse. Thus, this study aims to generate a reliable dataset on cardiac isoform expression pattern by long-read mRNA sequencing, followed by investigation of differential regulation of PGC-1α isoforms under metabolic and ischemic stress, using high-fat-high-sucrose-diet-induced obesity and a murine model of myocardial infarction.
Item Description:Gesehen am 19.08.2022
Physical Description:Online Resource
ISSN:1741-7007
DOI:10.1186/s12915-022-01360-w

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