Buchumschlag

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout lead...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Oehler, Daniel (VerfasserIn) , Spychala, André (VerfasserIn) , Gödecke, Axel (VerfasserIn) , Lang, Alexander (VerfasserIn) , Gerdes, Norbert (VerfasserIn) , Ruas, Jorge (VerfasserIn) , Kelm, Malte (VerfasserIn) , Szendrödi, Julia (VerfasserIn) , Westenfeld, Ralf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 30 July 2022
In: BMC biology
Year: 2022, Jahrgang: 20, Pages: 1-20
ISSN:1741-7007
DOI:10.1186/s12915-022-01360-w
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12915-022-01360-w
Volltext
Verfasserangaben:Daniel Oehler, André Spychala, Axel Gödecke, Alexander Lang, Norbert Gerdes, Jorge Ruas, Malte Kelm, Julia Szendroedi and Ralf Westenfeld
Beschreibung
Zusammenfassung:Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout leads to dilatative cardiomyopathy, but knowledge on the complexity of cardiac isoform expression of PGC-1α remains sparse. Thus, this study aims to generate a reliable dataset on cardiac isoform expression pattern by long-read mRNA sequencing, followed by investigation of differential regulation of PGC-1α isoforms under metabolic and ischemic stress, using high-fat-high-sucrose-diet-induced obesity and a murine model of myocardial infarction.
Beschreibung:Gesehen am 19.08.2022
Beschreibung:Online Resource
ISSN:1741-7007
DOI:10.1186/s12915-022-01360-w

Ähnliche Einträge