Cellular senescence in normal mammary gland and breast cancer: implications for cancer therapy
Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental dat...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 June 2022
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| In: |
Genes
Year: 2022, Volume: 13, Issue: 6, Pages: 1-10 |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes13060994 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/genes13060994 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4425/13/6/994 
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| Author Notes: | Chaido Sirinian, Stavros Peroukidis, Katharina Kriegsmann, Dimitrios Chaniotis, Angelos Koutras, Mark Kriegsmann and Anastasios D. Papanastasiou |
| Summary: | Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence. |
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| Item Description: | Gesehen am 24.08.2022 This article belongs to the special issue "Molecular therapeutics of breast cancer" |
| Physical Description: | Online Resource |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes13060994 |