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Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder

Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (EBV). We analysed intrathecal production of EBV viral capsid antigen (VCA) immunoglobulin (Ig)G and IgA and Epstein-Barr nuclear antigen-1 (EBNA-1) IgG in nine pati...

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Main Authors: Otto, Carolin (Author) , Radbruch, Helena (Author) , Wilken, Diana (Author) , Lietzow, Tatjana (Author) , Steinhagen, Katja (Author) , Grage-Griebenow, Evelin (Author) , von Brünneck, Ann-Christin (Author) , Jarius, Sven (Author) , Hofmann, Jörg (Author) , Pache, Florence (Author) , Ruprecht, Klemens (Author)
Format: Article (Journal)
Language:English
Published: 2 June 2022
In: Journal of neuroimmunology
Year: 2022, Volume: 369, Pages: 1-9
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2022.577902
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2022.577902
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572822000972
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Author Notes:Carolin Otto, Helena Radbruch, Diana Wilken, Tatjana Lietzow, Katja Steinhagen, Evelin Grage-Griebenow, Ann-Christin von Brünneck, Sven Jarius, Jörg Hofmann, Florence Pache, Klemens Ruprecht
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Summary:Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (EBV). We analysed intrathecal production of EBV viral capsid antigen (VCA) immunoglobulin (Ig)G and IgA and Epstein-Barr nuclear antigen-1 (EBNA-1) IgG in nine patients with PNCS-PTLD and 20 patients with non-inflammatory neurological diseases (NINDs). Intrathecally produced VCA-IgG was detected in 7/9 (78%), VCA-IgA in 6/9 (67%) and EBNA-1-IgG in 2/9 (22%) patients with PCNS-PTLD, but not in NINDs. This exploratory study suggests that intrathecal EBV antibody production might be frequent in PCNS-PTLD. Detecting intrathecally produced VCA-IgG and VCA-IgA could thus potentially be helpful for diagnosing PCNS-PTLD.
Item Description:Gesehen am 25.08.2022
Physical Description:Online Resource
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2022.577902

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