Neurodevelopment in normocephalic children exposed to Zika virus in utero with no observable defects at birth: a systematic review with meta-analysis
Zika virus (ZIKV) infection during pregnancy is a cause of pregnancy loss and multiple clinical and neurological anomalies in children. This systematic review aimed to assess the effect of ZIKV exposure in utero on the long-term neurodevelopment of normocephalic children born to women with ZIKV infe...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 June 2022
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| In: |
International journal of environmental research and public health
Year: 2022, Volume: 19, Issue: 12, Pages: 1-24 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph19127319 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijerph19127319 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1660-4601/19/12/7319 
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| Author Notes: | Elena Marbán-Castro, Laia J. Vazquez Guillamet, Percy Efrain Pantoja, Aina Casellas, Lauren Maxwell, Sarah B. Mulkey, Clara Menéndez and Azucena Bardají |
| Summary: | Zika virus (ZIKV) infection during pregnancy is a cause of pregnancy loss and multiple clinical and neurological anomalies in children. This systematic review aimed to assess the effect of ZIKV exposure in utero on the long-term neurodevelopment of normocephalic children born to women with ZIKV infection in pregnancy. This review was conducted according to the PRISMA guidelines for systematic reviews and meta-analyses. We performed a random effects meta-analysis to estimate the cross-study prevalence of neurodevelopmental delays in children using the Bayley Scales for Infant and Toddler Development (BSID-III). The risk of bias was assessed using Cochrane’s Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Full-text reviews were performed for 566 articles, and data were extracted from 22 articles corresponding to 20 studies. Nine articles including data from 476 children found 6.5% (95% CI: 4.1-9.3) of infants and children to have any type of non-language cognitive delay; 29.7% (95% CI: 21.7-38.2) to have language delay; and 11.5% (95% CI: 4.8-20.1) to have any type of motor delay. The pooled estimates had a high level of heterogeneity; thus, results should be interpreted with caution. Larger prospective studies that include a non-exposed control group are needed to confirm whether ZIKV exposure in utero is associated with adverse child neurodevelopmental outcomes. |
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| Item Description: | Gesehen am 25.08.2022 This article belongs to the special issue "Frontiers in maternal and reproductive health" |
| Physical Description: | Online Resource |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph19127319 |