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Comorbidities in recent-onset adult type 1 diabetes: a comparison of German cohorts

AimsRestrictive exclusion criteria from different study populations may limit the generalizability of the observations. By comparing two differently designed German cohorts, we assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diab...

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Main Authors: Zaharia, Oana-Patricia (Author) , Lanzinger, Stefanie (Author) , Rosenbauer, Joachim (Author) , Karges, Wolfram (Author) , Müssig, Karsten (Author) , Meyhöfer, Sebastian M. (Author) , Burkart, Volker (Author) , Hummel, Michael (Author) , Raddatz, Dirk (Author) , Roden, Michael (Author) , Szendrödi, Julia (Author) , Holl, Reinhard W. (Author)
Format: Article (Journal)
Language:English
Published: 03 June 2022
In: Frontiers in endocrinology
Year: 2022, Volume: 13, Pages: 1-11
ISSN:1664-2392
DOI:10.3389/fendo.2022.760778
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fendo.2022.760778
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2022.760778
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Author Notes:Oana P. Zaharia, Stefanie Lanzinger, Joachim Rosenbauer, Wolfram Karges, Karsten Müssig, Sebastian M. Meyhöfer, Volker Burkart, Michael Hummel, Dirk Raddatz, Michael Roden, Julia Szendroedi and Reinhard W. Holl for the GDS Group and the DPV Initiative
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Summary:AimsRestrictive exclusion criteria from different study populations may limit the generalizability of the observations. By comparing two differently designed German cohorts, we assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diabetes.MethodsThis study evaluated 1511 persons with type 1 diabetes of the prospective diabetes follow-up registry (DPV) and 268 volunteers of the prospective observational German Diabetes Study (GDS) with a known diabetes duration <1 year. Participants had similar age (36 years), sex distribution (41% female) and BMI (26 kg/m2) in both cohorts.ResultsThe average HbA1c was 6.4 ± 0.8% in the GDS and 7.0 ± 1.1% in the DPV. Prevalence of hypertension (24%) was similar, while more DPV participants had dyslipidemia and lipid-lowering medication than GDS participants (77% vs. 41% and 7% vs. 2%, respectively; p<0.05). Prevalence of retinopathy and nephropathy was higher in DPV compared to GDS participants (10% vs. 3% and 18% vs. 7%, respectively; p<0.001).ConclusionsDiabetic nephropathy and retinopathy are the most frequent complications in type 1 diabetes, affecting up to every 10th patient within the first year after diagnosis, underlining the need for more stringent risk factor management already at the time of diagnosis of type 1 diabetes.
Item Description:Gesehen am 26.08.2022
Physical Description:Online Resource
ISSN:1664-2392
DOI:10.3389/fendo.2022.760778

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