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Neurostructural traces of early life adversities: a meta-analysis exploring age- and adversity-specific effects

Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood...

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Main Authors: Pollok, Tania (Author) , Kaiser, Anna (Author) , Kraaijenvanger, Eline J. (Author) , Monninger, Maximilian (Author) , Brandeis, Daniel (Author) , Banaschewski, Tobias (Author) , Eickhoff, Simon B. (Author) , Holz, Nathalie E. (Author)
Format: Article (Journal)
Language:English
Published: 18 February 2022
In: Neuroscience & biobehavioral reviews
Year: 2022, Volume: 135, Pages: 1-15
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2022.104589
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neubiorev.2022.104589
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Author Notes:Tania M. Pollok, Anna Kaiser, Eline J. Kraaijenvanger, Maximilian Monninger, Daniel Brandeis, Tobias Banaschewski, Simon B. Eickhoff, Nathalie E. Holz
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Summary:Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects.
Item Description:Gesehen am 30.08.2022
Physical Description:Online Resource
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2022.104589

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