Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults
BACKGROUND: Air pollution is a risk factor for poor cognitive function, while a plant-based dietary pattern is associated with better cognitive function. We aimed to explore their interaction with cognitive function among older adults. - METHODS: We used a prospective cohort of old individuals, incl...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 January 2022
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| In: |
The lancet. Regional Health. Western Pacific
Year: 2022, Volume: 20, Pages: 1-12 |
| ISSN: | 2666-6065 |
| DOI: | 10.1016/j.lanwpc.2021.100372 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.lanwpc.2021.100372
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| Author Notes: | Anna Zhu, Hui Chen, Jie Shen, Xiaoxi Wang, Zhihui Li, Ai Zhao, Xiaoming Shi, Lijing Yan, Yi Zeng, Changzheng Yuan, and John S. Ji |
| Summary: | BACKGROUND: Air pollution is a risk factor for poor cognitive function, while a plant-based dietary pattern is associated with better cognitive function. We aimed to explore their interaction with cognitive function among older adults. - METHODS: We used a prospective cohort of old individuals, including 6525 participants of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), aged 65-110 years and with normal cognition at baseline. Air pollution measurement was derived using satellite-derived annual average fine particulate matter (PM2.5) concentrations based on residential locations. Plant-based diet index (PDI) was calculated using survey responses to assess the dietary pattern. Repeated measures of the Mini-Mental State Examination (MMSE) were utilized to assess cognitive function. We applied the Cox proportional hazard regression to explore the associations and further stratified the analysis by PDI. - FINDINGS: During a median of 5·6-year follow-up, 1537 (23·6%) out of 6525 participants with normal cognition at baseline developed poor cognitive function (MMSE <18). Living in areas with the highest quintile of cumulative PM2.5 was associated with a 46% increase in the risk of developing poor cognitive function (hazard ratio (HR): 1·46, 95% confidence interval (CI): 1·20, 1·77), compared to those living in areas with the lowest quintile. We observed a significant interaction between cumulative PM2.5 and PDI (p-interaction: 0·04), with the corresponding associations of cumulative PM2.5 being more pronounced among participants with lower PDI (HR: 1·68, 95% CI: 1·26, 2·24) than those with higher PDI (HR: 1·28, 95% CI: 0·98, 1·68). - INTERPRETATION: Plant-based dietary pattern may attenuate detrimental impacts of PM2.5 on cognitive function among older adults. Adherence to the plant-based dietary pattern could be used to prevent adverse neurological effects caused by air pollution, especially in developing regions. |
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| Item Description: | Gesehen am 02.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2666-6065 |
| DOI: | 10.1016/j.lanwpc.2021.100372 |