Reduced splenic uptake on 68Ga-Pentixafor-PET/CT imaging in multiple myeloma: a potential imaging biomarker for disease prognosis
Beyond being a key factor for tumor growth and metastasis in human cancer, C-X-C motif chemokine receptor 4 (CXCR4) is also highly expressed by a number of immune cells, allowing for non-invasive read-out of inflammatory activity. With two recent studies reporting on prognostic implications of the s...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022.08.08
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| In: |
Theranostics
Year: 2022, Volume: 12, Issue: 13, Pages: 5986-5994 |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.75847 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.7150/thno.75847 Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.7150%2Fthno.75847&DestApp=DOI&SrcAppSID=EUW1ED0CAApH9JposIpxHRX5Sw7oz&SrcJTitle=THERANOSTICS&DestDOIRegistrantName=Ivyspring+International+Publisher 
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| Author Notes: | Sabrina Kraus, Philipp Klassen, Malte Kircher, Alexander Dierks, Stefan Habringer, Alexander Gäble, Klaus Martin Kortüm, Niels Weinhold, Valëza Ademaj-Kospiri, Rudolf A. Werner, Andreas Schirbel, Andreas K. Buck, Peter Herhaus, Hans-Jürgen Wester, Andreas Rosenwald, Wolfgang A. Weber, Hermann Einsele, Ulrich Keller, Leo Rasche and Constantin Lapa |
| Summary: | Beyond being a key factor for tumor growth and metastasis in human cancer, C-X-C motif chemokine receptor 4 (CXCR4) is also highly expressed by a number of immune cells, allowing for non-invasive read-out of inflammatory activity. With two recent studies reporting on prognostic implications of the spleen signal in diffusion-weighted magnetic resonance imaging in patients with plasma cell dyscrasias, the aim of this study was to correlate splenic Ga-68-Pentixafor uptake in multiple myeloma (MM) with clinical parameters and to evaluate its prognostic impact. Methods: Eighty-seven MM patients underwent molecular imaging with Ga-68-Pentixafor-PET/CT. Splenic CXCR4 expression was semi-quantitatively assessed by peak standardized uptake values (SUVpeak) and corresponding spleen-to-bloodpool ratios (TBR) and correlated with clinical and prognostic features as well as survival parameters. Results: Ga-68-Pentixafor-PET/CT was visually positive in all MM patients with markedly heterogeneous tracer uptake in the spleen. CXCR4 expression determined by Ga-68-Pentixafor-PET/CT corresponded with advanced disease and was inversely associated with the number of previous treatment lines as compared to controls or untreated smouldering multiple myeloma patients (SUV(peak)Spleen 4.06 +/- 1.43 vs. 6.02 +/- 1.16 vs. 7.33 +/- 1.40; P < 0.001). Moreover, reduced splenic Ga-68-Pentixafor uptake was linked to unfavorable clinical outcome. Patients with a low SUV(peak)Spleen (<3.35) experienced a significantly shorter overall survival of 5 months as compared to 62 months in patients with a high SUV(peak)Spleen >5.79 (P < 0.001). Multivariate Cox analysis confirmed SUV(peak)Spleen as an independent predictor of survival (HR 0.75; P = 0.009). Conclusion: These data suggest that splenic Ga-68-Pentixafor uptake might provide prognostic information in pre-treated MM patients similar to what was reported for diffusion-weighted magnetic resonance imaging. Further research to elucidate the underlying biologic implications is warranted. |
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| Item Description: | Im Titel ist "68" hochgestellt Gesehen am 06.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.75847 |