The multifunctional role of EMP3 in the regulation of membrane receptors associated with IDH-wild-type glioblastoma
Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models hav...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 May 2021
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| In: |
International journal of molecular sciences
Year: 2021, Volume: 22, Issue: 10, Pages: 1-17 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22105261 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms22105261 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/22/10/5261 
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| Author Notes: | Antoni Andreu Martija and Stefan Pusch |
| Summary: | Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM. |
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| Item Description: | Gesehen am 07.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22105261 |