Synthesis of 5-Halo-4H-1,3-oxazine-6-amines by a copper-mediated domino reaction
Three become one! In one copper-mediated step, three simple components, including a propargylcarboxamide, a protected amine, and a source of chloride, assemble to give highly functionalized oxazines, which are interesting building blocks for the synthesis of other aminooxazine derivatives (see schem...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 April 2011
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| In: |
Chemistry - a European journal
Year: 2011, Volume: 17, Issue: 20, Pages: 5511-5515 |
| ISSN: | 1521-3765 |
| DOI: | 10.1002/chem.201100423 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/chem.201100423 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201100423 
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| Author Notes: | A. Stephen K. Hashmi, Andreas M. Schuster, Marc Zimmer, and Frank Rominger |
| Summary: | Three become one! In one copper-mediated step, three simple components, including a propargylcarboxamide, a protected amine, and a source of chloride, assemble to give highly functionalized oxazines, which are interesting building blocks for the synthesis of other aminooxazine derivatives (see scheme; R1=range of aryl or alkyl groups, R2=alkyl, EWG=electron-withdrawing group). |
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| Item Description: | Gesehen am 07.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1521-3765 |
| DOI: | 10.1002/chem.201100423 |