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C lamp-Cru shin g versus s tapler h epatectomy for transection of the parenchyma in elective hepatic resection (CRUNSH) - a randomized controlled trial (NCT01049607)

Background: Hepatic resection is still associated with significant morbidity. Although the period of parenchymal transection presents a crucial step during the operation, uncertainty persists regarding the optimal technique of transection. It was the aim of the present randomized controlled trial to...

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Main Authors: Rahbari, Nuh Nabi (Author) , Elbers, Heike (Author) , Koch, Moritz (Author) , Bruckner, Thomas (Author) , Vogler, Patrick (Author) , Striebel, Fabian (Author) , Schemmer, Peter (Author) , Mehrabi, Arianeb (Author) , Büchler, Markus W. (Author) , Weitz, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 04 September 2011
In: BMC surgery
Year: 2011, Volume: 11, Pages: 1-7
ISSN:1471-2482
DOI:10.1186/1471-2482-11-22
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2482-11-22
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Author Notes:Nuh N. Rahbari, Heike Elbers, Moritz Koch, Thomas Bruckner, Patrick Vogler, Fabian Striebel, Peter Schemmer, Arianeb Mehrabi, Markus W. Büchler and Jürgen Weitz
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Summary:Background: Hepatic resection is still associated with significant morbidity. Although the period of parenchymal transection presents a crucial step during the operation, uncertainty persists regarding the optimal technique of transection. It was the aim of the present randomized controlled trial to evaluate the efficacy and safety of hepatic resection using the technique of stapler hepatectomy compared to the simple clamp-crushing technique. Methods/Design: The CRUNSH Trial is a prospective randomized controlled single-center trial with a two-group parallel design. Patients scheduled for elective hepatic resection without extrahepatic resection at the Department of General-, Visceral- and Transplantation Surgery, University of Heidelberg are enrolled into the trial and randomized intraoperatively to hepatic resection by the clamp-crushing technique and stapler hepatectomy, respectively. The primary endpoint is total intraoperative blood loss. A set of general and surgical variables are documented as secondary endpoints. Patients and outcome-assessors are blinded for the treatment intervention. Discussion: The CRUNSH Trial is the first randomized controlled trial to evaluate efficacy and safety of stapler hepatectomy compared to the clamp-crushing technique for parenchymal transection during elective hepatic resection. Trial Registration: ClinicalTrials.gov: NCT01049607
Item Description:Gesehen am 08.09.2022
Physical Description:Online Resource
ISSN:1471-2482
DOI:10.1186/1471-2482-11-22

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