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Enhancing pancreatic adenocarcinoma delineation in diffusion derived intravoxel incoherent motion f-maps through automatic vessel and duct segmentation

Diffusion-based intravoxel incoherent motion imaging has recently gained interest as a method to detect and characterize pancreatic lesions, especially as it could provide a radiation- and contrast agent-free alternative to existing diagnostic methods. However, tumor delineation on intravoxel incohe...

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Hauptverfasser: Re, Thomas J. (VerfasserIn) , Lemke, Andreas (VerfasserIn) , Klauss, Miriam (VerfasserIn) , Laun, Frederik B. (VerfasserIn) , Simon, Dirk (VerfasserIn) , Grünberg, Katharina (VerfasserIn) , Delorme, Stefan (VerfasserIn) , Grenacher, Lars (VerfasserIn) , Manfredi, Riccardo (VerfasserIn) , Mucelli, Roberto Pozzi (VerfasserIn) , Stieltjes, Bram (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 2011
In: Magnetic resonance in medicine
Year: 2011, Jahrgang: 66, Heft: 5, Pages: 1327-1332
ISSN:1522-2594
DOI:10.1002/mrm.22931
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mrm.22931
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.22931
Volltext
Verfasserangaben:Thomas J. Re, Andreas Lemke, Miriam Klauss, Fredrik B. Laun, Dirk Simon, Katharina Grünberg, Stefan Delorme, Lars Grenacher, Riccardo Manfredi, Roberto Pozzi Mucelli, and Bram Stieltjes
Beschreibung
Zusammenfassung:Diffusion-based intravoxel incoherent motion imaging has recently gained interest as a method to detect and characterize pancreatic lesions, especially as it could provide a radiation- and contrast agent-free alternative to existing diagnostic methods. However, tumor delineation on intravoxel incoherent motion-derived parameter maps is impeded by poor lesion-to-pancreatic duct contrast in the f-maps and poor lesion-to-vessel contrast in the D-maps. The distribution of the diffusion and perfusion parameters within vessels, ducts, and tumors were extracted from a group of 42 patients with pancreatic adenocarcinoma. Clearly separable combinations of f and D were observed, and receiver operating characteristic analysis was used to determine the optimal cutoff values for an automated segmentation of vessels and ducts to improve lesion detection and delineation on the individual intravoxel incoherent motion-derived maps. Receiver operating characteristic analysis identified f = 0.28 as the cutoff for vessels (Area under the curve (AUC) = 0.901) versus tumor/duct and D = 1.85 μm2/ms for separating duct from tumor tissue (AUC = 0.988). These values were incorporated in an automatic segmentation algorithm and then applied to 42 patients. This yielded clearly improved tumor delineation compared to individual intravoxel incoherent motion-derived maps. Furthermore, previous findings that indicated that the f value in pancreatic cancer is strongly reduced compared to healthy pancreatic tissue were reconfirmed.
Beschreibung:Online veröffentlicht: 24. März 2011
Gesehen am 12.09.2022
Beschreibung:Online Resource
ISSN:1522-2594
DOI:10.1002/mrm.22931

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