Modular assembly of the principal microtubule nucleator γ-TuRC

The human microtubule nucleator γ-TuRC is composed of more than thirty subunits, including actin. Here the authors reveal the structural mechanism of modular γ-TuRC assembly and show a functional role of actin in microtubule nucleation.

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Bibliographic Details
Main Authors:	Würtz, Martin (Author) , Župa, Erik (Author) , Atorino, Enrico (Author) , Neuner, Annett (Author) , Böhler, Anna (Author) , Rahadian, Ariani S. (Author) , Vermeulen, Bram J. A. (Author) , Tonon, Giulia (Author) , Eustermann, Sebastian (Author) , Schiebel, Elmar (Author) , Pfeffer, Stefan (Author)
Format:	Article (Journal)
Language:	English
Published:	25 January 2022
In:	Nature Communications Year: 2022, Volume: 13, Pages: 1-16
ISSN:	2041-1723
DOI:	10.1038/s41467-022-28079-0
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-022-28079-0 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-022-28079-0
Author Notes:	Martin Würtz, Erik Zupa, Enrico S. Atorino, Annett Neuner, Anna Böhler, Ariani S. Rahadian, Bram J.A. Vermeulen, Giulia Tonon, Sebastian Eustermann, Elmar Schiebel & Stefan Pfeffer

Description
Summary:	The human microtubule nucleator γ-TuRC is composed of more than thirty subunits, including actin. Here the authors reveal the structural mechanism of modular γ-TuRC assembly and show a functional role of actin in microtubule nucleation.
Item Description:	Gesehen am 13.09.2022
Physical Description:	Online Resource
ISSN:	2041-1723
DOI:	10.1038/s41467-022-28079-0