Role of epigenetic mechanisms in chronic pain
Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage. When pain persists long after the injury has resolved, it becomes pathological. The precise molecular and cellular mechanisms causing the transition from acute to chronic pain are not fully understood. A key...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 August 2022
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| In: |
Cells
Year: 2022, Volume: 11, Issue: 16, Pages: 1-16 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells11162613 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells11162613 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/11/16/2613 
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| Author Notes: | Daniela Mauceri |
| Summary: | Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage. When pain persists long after the injury has resolved, it becomes pathological. The precise molecular and cellular mechanisms causing the transition from acute to chronic pain are not fully understood. A key aspect of pain chronicity is that several plasticity events happen along the neural pathways involved in pain. These long-lasting adaptive changes are enabled by alteration in the expression of relevant genes. Among the different modulators of gene transcription in adaptive processes in the nervous system, epigenetic mechanisms play a pivotal role. In this review, I will first outline the main classes of epigenetic mediators and then discuss their implications in chronic pain. |
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| Item Description: | Gesehen am 13.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells11162613 |