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PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial

The German Hodgkin Study Group's HD18 trial established the safety and efficacy of PET-guided eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses) for the treatment of advanced-stage Hodgkin lymphoma. However, because of a...

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Main Authors: Kreissl, Stefanie (Author) , Goergen, Helen (Author) , Buehnen, Ina (Author) , Kobe, Carsten (Author) , Moccia, Alden (Author) , Greil, Richard (Author) , Eichenauer, Dennis A (Author) , Zijlstra, Josée M (Author) , Markova, Jana (Author) , Meißner, Julia (Author) , Feuring-Buske, Michaela (Author) , Soekler, Martin (Author) , Beck, Hans-Joachim (Author) , Willenbacher, Wolfgang (Author) , Ludwig, Wolf-Dieter (Author) , Pabst, Thomas (Author) , Topp, Max S (Author) , Hitz, Felicitas (Author) , Bentz, Martin (Author) , Keller, Ulrich Bernd (Author) , Kühnhardt, Dagmar (Author) , Ostermann, Helmut (Author) , Hertenstein, Bernd (Author) , Aulitzky, Walter (Author) , Maschmeyer, Georg (Author) , Vieler, Tom (Author) , Eich, Hans (Author) , Baues, Christian (Author) , Stein, Harald (Author) , Fuchs, Michael (Author) , Diehl, Volker (Author) , Dietlein, Markus (Author) , Engert, Andreas (Author) , Borchmann, Peter (Author)
Format: Article (Journal)
Language:English
Published: 25 May 2021
In: The lancet. Haematology
Year: 2021, Volume: 8, Issue: 6, Pages: e398-e409
ISSN:2352-3026
DOI:10.1016/S2352-3026(21)00101-0
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/S2352-3026(21)00101-0
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2352302621001010
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Author Notes:Stefanie Kreissl, Helen Goergen, Ina Buehnen, Carsten Kobe, Alden Moccia, Richard Greil, Dennis A Eichenauer, Josée M Zijlstra, Jana Markova, Julia Meissner, Michaela Feuring-Buske, Martin Soekler, Hans-Joachim Beck, Wolfgang Willenbacher, Wolf-Dieter Ludwig, Thomas Pabst, Max S Topp, Felicitas Hitz, Martin Bentz, Ulrich Bernd Keller, Dagmar Kühnhardt, Helmut Ostermann, Bernd Hertenstein, Walter Aulitzky, Georg Maschmeyer, Tom Vieler, Hans Eich, Christian Baues, Harald Stein, Michael Fuchs, Volker Diehl, Markus Dietlein, Andreas Engert, Peter Borchmann
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Summary:The German Hodgkin Study Group's HD18 trial established the safety and efficacy of PET-guided eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses) for the treatment of advanced-stage Hodgkin lymphoma. However, because of a protocol amendment during the enrolment period (June 1, 2011) that changed standard treatment from eight to six cycles, the results of the HD18 trial have been partially immature. We report a prespecified 5-year follow-up analysis of the completed HD18 trial.
Item Description:Gesehen am 14.09.2022
Physical Description:Online Resource
ISSN:2352-3026
DOI:10.1016/S2352-3026(21)00101-0

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