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A hydrogel for adhesion prevention: characterization and efficacy study in a rabbit uterus model

Objective - Postoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels. - Study design - A physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PV...

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Bibliographic Details
Main Authors: Müller, Sascha A. (Author) , Weis, Christine (Author) , Odermatt, Erich K. (Author) , Knaebel, Hanns-Peter (Author) , Wente, Moritz N. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: European journal of obstetrics & gynecology and reproductive biology
Year: 2011, Volume: 158, Issue: 1, Pages: 67-71
ISSN:1872-7654
DOI:10.1016/j.ejogrb.2010.11.008
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejogrb.2010.11.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0301211510005567
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Author Notes:Sascha A. Müller, Christine Weis, Erich K. Odermatt, Hanns-Peter Knaebel, Moritz N. Wente
Description
Summary:Objective - Postoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels. - Study design - A physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PVA/CMC) hydrogel (A-Part) was characterized in vitro. Three different traumatization methods were evaluated in a rabbit uterine study. To determine its anti-adhesion efficacy, the hydrogel was first tested in an in vivo pilot study and then in a larger trial to compare it with icodextrin 4% solution (Adept®) and controls. - Results - Rheological measurements showed an increased elasticity of the hydrogel after freezing. In vivo experiments revealed a clear reduction in incidence, extent and severity of adhesions compared to the icodextrin 4% solution and the untreated control group. - Conclusions - These results warrant further investigation of the PVA/CMC A-Part hydrogel in clinical trials focused on gynaecological procedures.
Item Description:First published online: 10 December 2010
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Physical Description:Online Resource
ISSN:1872-7654
DOI:10.1016/j.ejogrb.2010.11.008

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