Inhibin-betaC subunit expression in normal and pathological human placental tissues
Inhibins and activins are important regulators of the female reproductive system. Recently, a novel inhibin betaC subunit has been identified. However, only limited data on the expression of this novel inhibin-betaC subunit in normal and pathological human placentas exist. Tissue specimens of normal...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Systems biology in reproductive medicine
Year: 2011, Volume: 57, Issue: 4, Pages: 197-203 |
| ISSN: | 1939-6376 |
| DOI: | 10.3109/19396368.2010.528505 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/19396368.2010.528505
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| Author Notes: | Ioannis Mylonas, Josef Makovitzky, Susanne Kunze, Ansgar Brüning, Franz Kainer, and Barbara Schiessl |
| Summary: | Inhibins and activins are important regulators of the female reproductive system. Recently, a novel inhibin betaC subunit has been identified. However, only limited data on the expression of this novel inhibin-betaC subunit in normal and pathological human placentas exist. Tissue specimens of normal, preeclamptic, hemolysis, elevated liver enzymes, low platelets (HELLP), and intrauterine growth restriction (IUGR) pregnancies (n = 24) were obtained at the conclusion of a cesarean section. Normal and pathological placental tissues were analyzed by an immunohistochemical staining reaction with a specific antibody against this novel inhibin-betaC subunit. Overall, expression of the inhibin-betaC subunit could be demonstrated in normal and pathological placental tissue. The immunoreactive score (IRS) for inhibin-betaC did not show any significant differences between normal, preeclamptic, HELLP, and IUGR tissue in extravillous trophoblast and syncytiotrophoblast cells. Immunolabelling of this novel inhibin-βC protein in normal and pathological placental tissue was demonstrated, although no differences in the staining intensity could be observed. Therefore, the inhibin-βC isoform might not primarily be involved in the pathogenesis of these pregnancy-associated disorders. The functional role of this novel inhibin-betaC subunit in normal and pathological human placenta is still quite unclear and should thus be further investigated. |
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| Item Description: | First published online: 30 Nov 2010 Gesehen am 15.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1939-6376 |
| DOI: | 10.3109/19396368.2010.528505 |