Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo
Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigatio...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Strahlentherapie und Onkologie
Year: 2011, Jahrgang: 187, Heft: 1, Pages: 45-51 |
| ISSN: | 1439-099X |
| DOI: | 10.1007/s00066-010-2116-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-010-2116-3
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| Verfasserangaben: | Frank Michael Klenke, Amir Abdollahi, Marc Bischof, Martha-Maria Gebhard, Volker Ewerbeck, Peter E. Huber, Axel Sckell |
MARC
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| 246 | 1 | |i Deutscher Titel der Zusammenfassung |a Celecoxib steigert die Strahlenempfindlichkeit von sekundären Knochentumoren eines nicht-kleinzelligen humanen Lungenkarzinoms durch Anti-Angiogenese in vivo | |
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| 520 | |a Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective COX-2 inhibitorcelecoxib in secondary bone tumors of a non-small cell lung carcinoma in vivo. | ||
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| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Bone tumor | |
| 650 | 4 | |a Cyclooxygenase | |
| 650 | 4 | |a Intravital microscopy | |
| 650 | 4 | |a Intravitalmikroskopie | |
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| 650 | 4 | |a Radiation | |
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