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Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo

Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigatio...

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Main Authors: Klenke, Frank Michael (Author) , Abdollahi, Amir (Author) , Bischof, Marc (Author) , Gebhard, Martha-Maria (Author) , Ewerbeck, Volker (Author) , Huber, Peter E. (Author) , Sckell, Axel (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Strahlentherapie und Onkologie
Year: 2011, Volume: 187, Issue: 1, Pages: 45-51
ISSN:1439-099X
DOI:10.1007/s00066-010-2116-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-010-2116-3
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Author Notes:Frank Michael Klenke, Amir Abdollahi, Marc Bischof, Martha-Maria Gebhard, Volker Ewerbeck, Peter E. Huber, Axel Sckell
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Summary:Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective COX-2 inhibitorcelecoxib in secondary bone tumors of a non-small cell lung carcinoma in vivo.
Item Description:Published online: December 23, 2010
Gesehen am 19.09.2022
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-010-2116-3

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