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Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo

Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigatio...

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Hauptverfasser: Klenke, Frank Michael (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Bischof, Marc (VerfasserIn) , Gebhard, Martha-Maria (VerfasserIn) , Ewerbeck, Volker (VerfasserIn) , Huber, Peter E. (VerfasserIn) , Sckell, Axel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Strahlentherapie und Onkologie
Year: 2011, Jahrgang: 187, Heft: 1, Pages: 45-51
ISSN:1439-099X
DOI:10.1007/s00066-010-2116-3
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-010-2116-3
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Verfasserangaben:Frank Michael Klenke, Amir Abdollahi, Marc Bischof, Martha-Maria Gebhard, Volker Ewerbeck, Peter E. Huber, Axel Sckell
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Zusammenfassung:Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhancethe response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases.Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective COX-2 inhibitorcelecoxib in secondary bone tumors of a non-small cell lung carcinoma in vivo.
Beschreibung:Published online: December 23, 2010
Gesehen am 19.09.2022
Beschreibung:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-010-2116-3

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