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Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin

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Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four week...

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Main Authors: Rodrigues, Pedro N. S. (Author) , Gomes, Sandro S. (Author) , Neves, João V. (Author) , Gomes-Pereira, Sandra (Author) , Correia-Neves, Margarida (Author) , Nunes-Alves, Cláudio (Author) , Stolte, Jens (Author) , Sanchez, Mayka (Author) , Appelberg, Rui (Author) , Muckenthaler, Martina (Author) , Gomes, M. Salomé (Author)
Format: Article (Journal)
Language:English
Published: 20 April 2011
In: Immunobiology
Year: 2011, Volume: 216, Issue: 10, Pages: 1127-1134
ISSN:1878-3279
DOI:10.1016/j.imbio.2011.04.004
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.imbio.2011.04.004
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0171298511000751
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Author Notes:Pedro N. Rodrigues, Sandro S. Gomes, João V. Neves, Sandra Gomes-Pereira, Margarida Correia-Neves, Cláudio Nunes-Alves, Jens Stolte, Mayka Sanchez, Rui Appelberg, Martina U. Muckenthaler, M. Salomé Gomes
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Summary:Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (Slc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2.
Item Description:Gesehen am 19.09.2022
Physical Description:Online Resource
ISSN:1878-3279
DOI:10.1016/j.imbio.2011.04.004

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