Repeated linac-based radiosurgery in high-grade cerebral arteriovenous-malformations (AVM) Spetzler-Martin grade III to IV previously treated with radiosurgery
Background - Aim was to access outcome and toxicity of repeated linac-based radiosurgery in incompletely obliterated cerebral AVM. - Patients and methods - Between 1998 and 2008, 11 patients were treated with repeated radiosurgery. The median dose to the 80%-isodose was 15Gy (range, 12-18Gy). During...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[February 2011]
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| In: |
Radiotherapy and oncology
Year: 2011, Volume: 98, Issue: 2, Pages: 217-222 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2011.01.002 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2011.01.002 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814011000168 
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| Author Notes: | Henrik Hauswald, Stefanie Milker-Zabel, Florian Sterzing, Wolfgang Schlegel, Juergen Debus, Angelika Zabel-du Bois |
| Summary: | Background - Aim was to access outcome and toxicity of repeated linac-based radiosurgery in incompletely obliterated cerebral AVM. - Patients and methods - Between 1998 and 2008, 11 patients were treated with repeated radiosurgery. The median dose to the 80%-isodose was 15Gy (range, 12-18Gy). During initial radiosurgery the median dose was 18Gy (range, 9-22Gy). - Results - The median time interval between initial radiosurgery and re-treatment was 9years (range, 4-16years). The median follow-up was 26months (range, 2-115months). Treatment response was seen in 8 patients (89%). Complete (partial) obliteration was achieved in 5 (3) patients (56%, 33%, respectively).The median time to complete obliteration was 26months (range, 5-45months). Pre-existing neurological symptoms improved in 2 patients (18%), were stable in 7 patients (64%) and worsened in 2 patients (18%). Prevalence of intracranial hemorrhage was 9% (1/11). Post-re-treatment intracranial hemorrhage rate was 2.7% (1/38years at risk). During follow-up, no secondary malignancies or toxicity>grade III were observed. - Conclusion - Repeated linac-based radiosurgery in incompletely obliterated cerebral AVM is an effective treatment option with a high rate of treatment response and an acceptable risk for side effects. Marginal doses above 15Gy might further improve the rate of complete obliterations. |
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| Item Description: | Gesehen am 23.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2011.01.002 |