Phosphorylation of LRP1 regulates the interaction with Fe65
Neuronal Fe65 is a central adapter for the intracellular protein network of Alzheimer’s diseaserelated amyloid precursor protein (APP). It contains a unique tandem array of phosphotyrosine-binding (PTB) domains that recognize NPXY internalization motifs present in the intracellulardomains of APP (AI...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 September 2011
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| In: |
FEBS letters
Year: 2011, Volume: 585, Issue: 20, Pages: 3229-3235 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2011.09.028 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.febslet.2011.09.028 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2011.09.028 
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| Author Notes: | Wilfried Klug, Andreas Dietl, Bernd Simon, Irmgard Sinning, Klemens Wild |
| Summary: | Neuronal Fe65 is a central adapter for the intracellular protein network of Alzheimer’s diseaserelated amyloid precursor protein (APP). It contains a unique tandem array of phosphotyrosine-binding (PTB) domains that recognize NPXY internalization motifs present in the intracellulardomains of APP (AICD) and the low-density lipoprotein receptor-related protein LRP1 (LICD). Theternary APP/Fe65/LRP1 complex is an important mediator of APP processing and affectsb-amyloidpeptide production. Here we dissect by biochemical and biophysical methods the direct interactionswithin the ternary complex and reveal a phosphorylation-dependent insulin receptor substrate(IRS-) like interaction of the distal NPVY4507motif of LICD with Fe65-PTB1. |
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| Item Description: | Gesehen am 26.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2011.09.028 |