Two-photon vision in age-related macular degeneration: a translational study
The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Mic...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 March 2022
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| In: |
Diagnostics
Year: 2022, Volume: 12, Issue: 3, Pages: 1-12 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12030760 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics12030760 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/12/3/760 
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| Author Notes: | Grzegorz Łabuz, Agnieszka Zielińska, Lucy J. Kessler, Asu Rayamajhi, Katarzyna Komar, Ramin Khoramnia and Gerd U. Auffarth |
| Summary: | The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Microperimetry was performed with visible (white) light and infrared (IR) light, which was perceived as green in the two-photon stimulation. In total, 45 subjects were included with one (better) eye studied. Furthermore, best-corrected visual acuity (VA) and ocular straylight were assessed. AMD resulted in decreased median (interquartile range) logMAR VA, i.e., 0.15 (0.05; 0.24), which in normal eyes was −0.02 (−0.06; 0.02). The two groups showed comparable straylight levels. Sensitivity to IR light was significantly lower in the AMD group (p < 0.001): 8.3 (7.4, 9.3) dB than in controls 10.7 (9.7, 11.2) dB. AMD also significantly affected visible light sensitivity (p < 0.001): 14.0 (11.0; 15.5) dB vs. 18.0 (16.3; 18.9) dB. Notably, the two-photon approach yielded a lower data spread. In conclusion, AMD considerably impairs retinal sensitivity measured in the single- and two-photon realm. However, two-photon-vision microperimetry may improve the testing accuracy and offer an additional diagnostic parameter (beyond VA measurements) for retinal function assessment. |
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| Item Description: | Published: 21 March 2022 Gesehen am 26.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12030760 |