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The OECD validation program of the H295R steroidogenesis assay: phase 3. Final inter-laboratory validation study

In response to increasing concerns regarding the potential of chemicals to interact with the endocrine system of humans and wildlife, various national and international programs have been initiated with the aim to develop new guidelines for the screening and testing of these chemicals in vertebrates...

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Main Authors: Hecker, Markus (Author) , Hollert, Henner (Author) , Cooper, Ralph (Author) , Vinggaard, Anne Marie (Author) , Akahori, Yumi (Author) , Murphy, Margaret (Author) , Nellemann, Christine (Author) , Higley, Eric (Author) , Newsted, John (Author) , Laskey, John (Author) , Buckalew, Angela (Author) , Grund, Stefanie (Author) , Maletz, Sibylle (Author) , Giesy, John (Author) , Timm, Gary (Author)
Format: Article (Journal)
Language:English
Published: [2011]
In: Environmental science and pollution research
Year: 2011, Volume: 18, Issue: 3, Pages: 503-515
ISSN:1614-7499
DOI:10.1007/s11356-010-0396-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11356-010-0396-x
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Author Notes:Markus Hecker, Henner Hollert, Ralph Cooper, Anne Marie Vinggaard, Yumi Akahori, Margaret Murphy, Christine Nellemann, Eric Higley, John Newsted, John Laskey, Angela Buckalew, Stefanie Grund, Sibylle Maletz, John Giesy, Gary Timm
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Summary:In response to increasing concerns regarding the potential of chemicals to interact with the endocrine system of humans and wildlife, various national and international programs have been initiated with the aim to develop new guidelines for the screening and testing of these chemicals in vertebrates. Here, we report on the validation of an in vitro assay, the H295R steroidogenesis assay, to detect chemicals with the potential to inhibit or induce the production of the sex steroid hormones testosterone (T) and 17β-estradiol (E2) in preparation for the development of an Organization for Economic Cooperation and Development (OECD) test guideline.
Item Description:Published: 03 October 2010
Gesehen am 28.09.2022
Physical Description:Online Resource
ISSN:1614-7499
DOI:10.1007/s11356-010-0396-x

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