The impact of the glial spatial buffering on the K+ Nernst potential
Astrocytes play a critical role in CNS metabolism, regulation of volume and ion homeostasis of the interstitial space. Of special relevance is their clearance of K+ that is released by active neurons into the extracellular space. Mathematical analysis of a modified Nernst equation for the electroche...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 July 2011
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| In: |
Cognitive neurodynamics
Year: 2011, Volume: 5, Issue: 3, Pages: 285-291 |
| ISSN: | 1871-4099 |
| DOI: | 10.1007/s11571-011-9165-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11571-011-9165-x
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| Author Notes: | H.R. Noori |
| Summary: | Astrocytes play a critical role in CNS metabolism, regulation of volume and ion homeostasis of the interstitial space. Of special relevance is their clearance of K+ that is released by active neurons into the extracellular space. Mathematical analysis of a modified Nernst equation for the electrochemical equilibrium of neuronal plasma membranes, suggests that K+ uptake by glial cells is not only relevant during neuronal activity but also has a non-neglectable impact on the basic electrical membrane properties, specifically the resting membrane potential, of neurons and might be clinically valuable as a factor in the genetics and epigenetics of the epilepsy and tuberous sclerosis complex. |
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| Item Description: | Gesehen am 28.09.2022 Im Titel ist das Pluszeichen hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1871-4099 |
| DOI: | 10.1007/s11571-011-9165-x |