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From catalysts to bioactive organometallics: Do grubbs catalysts trigger biological effects?

Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activit...

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Bibliographic Details
Main Authors: Oehninger, Luciano (Author) , Alborzinia, Hamed (Author) , Ludewig, Stephanie (Author) , Baumann, Knut (Author) , Wölfl, Stefan (Author) , Ott, Ingo (Author)
Format: Article (Journal) Editorial
Language:English
Published: 07 September 2011
In: ChemMedChem
Year: 2011, Volume: 6, Issue: 12, Pages: 2142-2145
ISSN:1860-7187
DOI:10.1002/cmdc.201100308
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/cmdc.201100308
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201100308
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Author Notes:Luciano Oehninger, Hamed Alborzinia, Stephanie Ludewig, Knut Baumann, Stefan Wölfl, and Ingo Ott
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Summary:Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activity suggests that incorporating aspects of their structures could be beneficial for drug design.
Item Description:Gesehen am 29.09.2022
Physical Description:Online Resource
ISSN:1860-7187
DOI:10.1002/cmdc.201100308

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