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From catalysts to bioactive organometallics: Do grubbs catalysts trigger biological effects?

Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activit...

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Bibliographische Detailangaben
Hauptverfasser: Oehninger, Luciano (VerfasserIn) , Alborzinia, Hamed (VerfasserIn) , Ludewig, Stephanie (VerfasserIn) , Baumann, Knut (VerfasserIn) , Wölfl, Stefan (VerfasserIn) , Ott, Ingo (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: 07 September 2011
In: ChemMedChem
Year: 2011, Jahrgang: 6, Heft: 12, Pages: 2142-2145
ISSN:1860-7187
DOI:10.1002/cmdc.201100308
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/cmdc.201100308
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201100308
Volltext
Verfasserangaben:Luciano Oehninger, Hamed Alborzinia, Stephanie Ludewig, Knut Baumann, Stefan Wölfl, and Ingo Ott
Beschreibung
Zusammenfassung:Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activity suggests that incorporating aspects of their structures could be beneficial for drug design.
Beschreibung:Gesehen am 29.09.2022
Beschreibung:Online Resource
ISSN:1860-7187
DOI:10.1002/cmdc.201100308

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