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Ellagic acid: a review on its natural sources, chemical stability, and therapeutic potential

Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimer...

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Main Authors: Sharifi-Rad, Javad (Author) , Quispe, Cristina (Author) , Castillo, Carla Marina Salgado (Author) , Caroca, Rodrigo (Author) , Lazo-Vélez, Marco A. (Author) , Antonyak, Halyna (Author) , Polishchuk, Alexandr (Author) , Lysiuk, Roman (Author) , Oliinyk, Petro (Author) , De Masi, Luigi (Author) , Bontempo, Paola (Author) , Martorell, Miquel (Author) , Daştan, Sevgi Durna (Author) , Rigano, Daniela (Author) , Wink, Michael (Author) , Cho, William C. (Author)
Format: Article (Journal)
Language:English
Published: 21 February 2022
In: Oxidative medicine and cellular longevity
Year: 2022, Volume: 2022, Pages: 1-24
ISSN:1942-0994
DOI:10.1155/2022/3848084
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2022/3848084
Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/omcl/2022/3848084/
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Author Notes:Javad Sharifi-Rad, Cristina Quispe, Carla Marina Salgado Castillo, Rodrigo Caroca, Marco A. Lazo-Vélez, Halyna Antonyak, Alexandr Polishchuk, Roman Lysiuk, Petro Oliinyk, Luigi De Masi, Paola Bontempo, Miquel Martorell, Sevgi Durna Daştan, Daniela Rigano, Michael Wink, and William C. Cho
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Summary:Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
Item Description:Special issue "Phytochemicals for the Prevention and Treatment of Oxidative Stress-Induced Diseases"
Gesehen am 04.10.2022
Physical Description:Online Resource
ISSN:1942-0994
DOI:10.1155/2022/3848084

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