Dengue vaccine development: challenges and prospects
Purpose of review - Dengue vaccine development is a high public health priority. To date, no dengue vaccine is in widespread use. Here we review the challenges in dengue development and the latest results for the second-generation dengue vaccines. - Recent findings - The biggest hurdle is th...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
Current opinion in infectious diseases
Year: 2022, Volume: 35, Issue: 5, Pages: 390-396 |
| ISSN: | 1473-6527 |
| DOI: | 10.1097/QCO.0000000000000871 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/QCO.0000000000000871 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/co-infectiousdiseases/Abstract/2022/10000/Dengue_vaccine_development__challenges_and.4.aspx 
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| Author Notes: | Annelies Wilder-Smith |
| Summary: | Purpose of review - Dengue vaccine development is a high public health priority. To date, no dengue vaccine is in widespread use. Here we review the challenges in dengue development and the latest results for the second-generation dengue vaccines. - Recent findings - The biggest hurdle is the immunological interaction between the four antigenically distinct dengue serotypes. The advantages of second-generation dengue vaccines are the inclusion of nonstructural proteins of the dengue backbone and a more convenient dosing with reduced numbers of doses needed. - Summary - Although dengue-primed individuals can already benefit from vaccination with the first licensed dengue vaccine CYD-TDV, the public health need for the dengue-naive population has not yet been met. The urgent need remains to identify correlates of both protection and enhancement; until such correlates have been identified, all second-generation dengue vaccines still need to go through full phase 3 trials. The 5-year efficacy and safety data for both second-generation dengue vaccines are imminent. |
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| Item Description: | Gesehen am 11.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1473-6527 |
| DOI: | 10.1097/QCO.0000000000000871 |